CELLULAR AND MOLECULAR MECHANISMS OF MUSCLE REGENERATION
نویسندگان
چکیده
BACKGROUND: Muscle injuries are a common manifestation of exercise and non-mechanical factors such as drugs, genetic defects, systemic diseases. Despite their clinical importance, the cellular molecular mechanisms muscle injury repair poorly understood, which hamper development effective interventions. OBJECTIVE: This review is an attempt to recognize basic principles skeletal regeneration process. METHODS: A thorough systematic articles on processes was conducted using three reliable search engines for biomedical literature ScienceDirect, Scopus PubMed. REVIEW: Following injury, rapid activation differentiation satellite cells major At levels, dysferlin MG53 proteins help in building ‘’repair cap’’ at site initiate event followed by secretion myokines subsequent infiltration macrophages into fibers, remove debris activate other cells. elaborates regulating these events following injury. Effective therapeutic interventions counter injury-related atrophy remain elusive. Conclusion: Altogether, this proposes targets accelerate process mechanical injuries. Further investigations required elucidate pathways dictating
منابع مشابه
Cellular and molecular regulation of muscle regeneration.
Under normal circumstances, mammalian adult skeletal muscle is a stable tissue with very little turnover of nuclei. However, upon injury, skeletal muscle has the remarkable ability to initiate a rapid and extensive repair process preventing the loss of muscle mass. Skeletal muscle repair is a highly synchronized process involving the activation of various cellular responses. The initial phase o...
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ژورنال
عنوان ژورنال: Khyber Medical University Journal
سال: 2021
ISSN: ['2305-2643', '2305-2651']
DOI: https://doi.org/10.35845/kmuj.2021.20319